Pyridinium analogues of green fluorescent protein chromophore: Fluorogenic dyes with large solvent-dependent Stokes shifts
Novel fluorogenic dyes based on the GFP chromophore are developed. The compounds contain a pyridinium ring instead of phenolate and feature large Stokes shifts and solvent-dependent variations in the fluorescence quantum yield, which facilitates their use for imaging the membrane structure of endoplasmic reticulum (ER). Electronic structure calculations explain the trends in solvatochromic behavior. Related ResearchUnderstanding photoactive proteins in gas phase and in realistic environments |
Funding is provided by:
 National Science Foundation |  U.S. Department of Energy |  U.S. Army Research Laboratory |  USC Dornsife College of Letters, Arts, and Sciences |
Contact info
SSC-409, University of Southern California
Los Angeles, CA 90089-0482
Phone: 213-740-4929 (Prof. Krylov), 213-740-0893 (Lab)
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